Publication Name	World Journal of Clinical Oncology
Manuscript ID	109711
Country	United States

Category	Oncology
Manuscript Type	Editorial
Article Title	Swollen lymph node metastasis in gastric cancer: A forgotten prognostic signal in need of clinical action
Manuscript Source	Invited Manuscript
All Author List	Keykavous Parang and Amir Nasrolahi Shirazi
Funding Agency and Grant Number
Corresponding Author	Keykavous Parang, PharmD, PhD, Tenured Professor, Department of Biomedical and Pharmaceutical Sciences, Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, No. 9401 Jeronimo Road, Irvine, CA 92618, United States, 9401 Jeronimo Road, Chapman University, School of Pharmacy, Irvine, CA 92618, USA. parang@chapman.edu., Irvine, California 92618, United States. parang@chapman.edu
Key Words	Gastric cancer; Lymph node metastasis; Neoadjuvant chemotherapy; Precision oncology; Prognosis; Staging; Swollen lymph node
Core Tip	Swollen lymph node metastasis (SLNM), defined by bulky nodal tumor deposits (> 3 cm on imaging or multiple > 1.5 cm nodes) in gastric cancer, confers a dramatically worse outcome. In a large recent cohort, SLNM was independently associated with approximately 50% higher mortality risk. This editorial emphasizes SLNM’s under-recognized prognostic value. Formally incorporating SLNM into gastric cancer staging and treatment algorithms (for example, prioritizing neoadjuvant chemotherapy) may improve risk stratification. Recognizing SLNM as a biomarker can enhance precision oncology approaches by identifying patients for intensified multimodal therapy.
Citation	Parang K, Shirazi AN. Swollen lymph node metastasis in gastric cancer: A forgotten prognostic signal in need of clinical action. World J Clin Oncol 2025; In press

Received	2025-05-19 14:53
Peer-Review Started	2025-05-19 14:53
To Make the First Decision
Return for Revision	2025-06-05 09:38
Revised	2025-06-15 03:12
Second Decision	2025-07-09 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-09 08:05
Articles in Press	2025-07-09 08:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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