Publication Name	World Journal of Clinical Oncology
Manuscript ID	109736
Country	Türkiye

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Advancing early detection of gastric cancer through serum cytokine profiling
Manuscript Source	Invited Manuscript
All Author List	Duygu Kirkik, Yesim Uygun Kızmaz and Sevgi Kalkanli Tas
Funding Agency and Grant Number
Corresponding Author	Duygu Kirkik, PhD, Department of Immunology, Hamidiye Medicine Faculty, University of Health Sciences, Mekteb-i Tıbbiyye-i Şâhane (Haydarpaşa) Külliyesi Selimiye Mah Tıbbiye Cad No. 38, Istanbul 34668, Türkiye. dygkirkik@gmail.com
Key Words	Gastric carcinoma; Cytokines; Interleukin-6; Interleukin-8; Interleukin-10; Tumour necrosis factor-alpha; Interferon-gamma; Biomarkers; Inflammation; Diagnosis
Core Tip	Ren et al’s study produced some main findings that suggest serum pro-inflammatory cytokines may serve as potential biomarkers for the diagnosis of gastric carcinoma (GC). This study reveals that patients with GC have significantly elevated levels of interleukin (IL)-1β, IL-6, IL-8, and interferon-γ compared to healthy individuals. Notably, the receiver operating characteristic curve analysis demonstrates that IL-1β, IL-6, and IL-8 show exceptional potential in distinguishing GC patients, with area under the curve values exceeding 0.7. Furthermore, a positive correlation was found between the serum levels of IL-1β and IL-6 and both the T stage and N stage of the disease. These insights encourage further exploration and offer hope for advancements in gastric cancer diagnostics. In addition to this, there are several limitations to consider. One major limitation is the relatively small sample size, as well as the potential bias introduced by collecting data from a single center. Furthermore, the study did not evaluate the dynamic changes in pro-inflammatory cytokines at various stages of GC. Lastly, it is worth noting that the samples were collected over an extended period, nearly one year.
Citation	Kirkik D, Uygun Kızmaz Y, Kalkanli Tas S. Advancing early detection of gastric cancer through serum cytokine profiling. World J Clin Oncol 2025; In press

Received	2025-05-20 06:52
Peer-Review Started	2025-05-20 06:52
To Make the First Decision
Return for Revision	2025-06-05 09:38
Revised	2025-06-28 14:37
Second Decision	2025-09-08 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 07:56
Articles in Press	2025-09-08 07:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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