Publication Name	World Journal of Cardiology
Manuscript ID	109739
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Atrial fibrillation substrate mapping with emphasis on voltage-based guidance
Manuscript Source	Invited Manuscript
All Author List	Edward J Ciaccio, Henry H Hsia, Hirad Yarmohammadi, Elaine Y Wan MD, Nicholas S Peters, Deepak Saluja and Angelo B Biviano
Funding Agency and Grant Number
Corresponding Author	Edward J Ciaccio, PhD, Senior Researcher, Division of Cardiology, Department of Medicine, Columbia University Medical Center, Room 9-934, 180 Fort Washington Avenue, New York, NY 10032, United States. ejc6@columbia.edu
Key Words	Ablation; Atrial fibrillation; Sinus rhythm; Substrate mapping; Voltage
Core Tip	Voltage mapping is commonly used during substrate mapping to detect target areas for ablation in patients with atrial fibrillation (AF). Analysis of the substrate may take the form of detecting low voltage areas or the average voltage over an entire region. Often, areas which are targets for ablation are located where the voltage level is lower than normal, indicating disease and damage to the substrate. Furthermore, as AF progresses from paroxysmal to persistent type, the voltage level of the left atrium tends to diminish. This is often associated with atrial remodeling, in which structural and electrical changes occur during arrhythmia. Protocols for finding target areas using voltage mapping are described, and future research efforts to improve mapping and outcome are discussed.
Citation	Ciaccio EJ, Hsia HH, Yarmohammadi H, MD EYW, Peters NS, Saluja D, Biviano AB. Atrial fibrillation substrate mapping with emphasis on voltage-based guidance. World J Cardiol 2025; In press

Received	2025-05-20 06:53
Peer-Review Started	2025-05-20 06:54
To Make the First Decision
Return for Revision	2025-06-12 07:35
Revised	2025-06-16 22:30
Second Decision	2025-09-16 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-16 07:00
Articles in Press	2025-09-16 07:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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