Publication Name	World Journal of Methodology
Manuscript ID	109784
Country	India

Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Innovative prospects in 3D printed bio-scaffolds for osteochondral tissue engineering: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Madhan Jeyaraman, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Shrideavi Murugan and Sathish Muthu
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	3D printing; Tissue engineers; Osteochondral tissue engineering; Extracellular matrix; Cartilage
Core Tip	Advancements in 3D printing have revolutionized osteochondral tissue engineering by enabling biomimetic scaffolds that replicate native tissue complexities. These scaffolds support cellular adhesion, proliferation, and differentiation while maintaining mechanical integrity and biodegradability. Innovative techniques, such as laser-assisted bioprinting and bio-inks enriched with nanoparticles, enhance functionality and regeneration. However, challenges persist in scalability, reproducibility, and clinical translation. Future directions, including 4D printing and smart biomaterials, offer promising solutions for personalized treatments.
Citation	Jeyaraman M, Jeyaraman N, Nallakumarasamy A, Murugan S, Muthu S. Innovative prospects in 3D printed bio-scaffolds for osteochondral tissue engineering: A systematic review. World J Methodol 2025; In press

Received	2025-05-21 12:39
Peer-Review Started	2025-05-21 12:39
To Make the First Decision
Return for Revision	2025-06-07 04:21
Revised	2025-06-28 06:50
Second Decision	2025-10-13 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-13 11:59
Articles in Press	2025-10-13 11:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com