Publication Name	World Journal of Gastroenterology
Manuscript ID	109808
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Comparative evaluation of three traditional herbal formulas on gastrointestinal motility in a mouse model of cold stress-induced dyspepsia
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Hua Wang, Song-Yi Han, Liangliang Wu, Uijeong Han, Si-Kyung Cho, Chan-Woong Park, Young-Won Chin, Mi Young Lim and Hojun Kim
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea No. 2022M3A9E4017033
Corresponding Author	Hojun Kim, Division of Rehabilitation Medicine of Korean Medicine, Department of Oriental Rehabilitation Medicine, Dongguk University, Ilsan Hospital, 27 Dongguk-ro, Goyang 10326, South Korea. kimklar@dongguk.ac.kr
Key Words	Non-alcoholic fatty liver disease; Alcoholic liver disease; Non-alcoholic steatohepatitis; Insulin resistance; Oxidative stress
Core Tip	This study systematically compared the therapeutic effects of three classical herbal formulas (Pyeongwi-san, Shihosogan-tang, and Yijung-tang) in a mouse model of cold stress-induced dyspepsia. Among them, Pyeongwi-san was the most effective in restoring gastrointestinal motility, enhancing gastric acid secretion and upregulating digestive enzymes gene expression, and modulating serotonin, short-chain fatty acids, bile acid receptors, and glucagon-like peptide-1 signaling. These findings elucidate the mechanisms of Pyeongwi-san’s superior efficacy and strongly support its clinical application in treating cold-induced gastrointestinal dysfunction.
Citation	Wang JH, Han SY, Wu L, Han U, Cho SK, Park CW, Chin YW, Lim MY, Kim H. Comparative evaluation of three traditional herbal formulas on gastrointestinal motility in a mouse model of cold stress-induced dyspepsia. World J Gastroenterol 2025; In press

Received	2025-05-23 03:03
Peer-Review Started	2025-05-23 03:03
To Make the First Decision
Return for Revision	2025-06-11 07:24
Revised	2025-06-24 08:11
Second Decision	2025-08-14 03:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 00:41
Articles in Press	2025-08-15 00:41
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ISSN	1007-9327 (print) and 2219-2840 (online)
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