Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	109830
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Tumor microenvironment phenotyping guides precision therapy in unresectable pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Kai Zhao, Ming-Ming Xiao, Yong-Sheng Yang and Xiao Xiao
Funding Agency and Grant Number
Corresponding Author	Xiao Xiao, MD, PhD, Research Fellow, Department of Endocrinology, Weifang People’s Hospital, No. 151 Guangwen Street, Kuiwen District, Weifang 261041, Shandong Province, China. xiaoxiao9011@sdsmu.edu.cn
Key Words	Locally advanced unresectable pancreatic cancer; Gemcitabine; Nano-albumin paclitaxel; Tumor microenvironmental resistance; Combination therapy
Core Tip	This review highlights the importance of tumor microenvironment (TME) heterogeneity in treatment resistance for unresectable locally advanced pancreatic cancer. We propose a novel four-dimensional TME phenotyping framework integrating fibrosis, immunity, genomics, and metabolism to guide precision therapy. This approach enables dynamic, individualized treatment strategies and offers new prospects for improving patient outcomes.
Citation	Zhao K, Xiao MM, Yang YS, Xiao X. Tumor microenvironment phenotyping guides precision therapy in unresectable pancreatic cancer. World J Gastrointest Oncol 2025; In press

Received	2025-05-23 05:56
Peer-Review Started	2025-05-23 05:56
To Make the First Decision
Return for Revision	2025-05-29 08:50
Revised	2025-06-09 16:02
Second Decision	2025-09-08 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 08:34
Articles in Press	2025-09-08 08:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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