Publication Name	World Journal of Stem Cells
Manuscript ID	109862
Country	Egypt

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Mesenchymal stem-derived exosomes enhance therapeutic benefits of exercise in isoproterenol-induced myocardial ischemia: Targeting ERK and Akt/mTOR signaling
Manuscript Source	Invited Manuscript
All Author List	Asmaa M ShamsEldeen, Manar M AbdElalim, Nahed S Mohamed, Marwa M AbdelRahman, Samaa S Kamar, Dina H AbdelKader, Samar H Elsharkawy, Laila A Rashed, Salwa S Faisal, Walla’a A Osman and Asmaa M Selmy
Funding Agency and Grant Number
Corresponding Author	Asmaa M ShamsEldeen, Assistant Professor, MD, Department of Physiology, Cairo University, Al-Saray Street, El Manial, Cairo 30411, Egypt. asmaa82shamseldeen@gmail.com
Key Words	Myocardial infarction; Exercise; Exosomes; Sarcoplasmic endoplasmic reticulum calcium ATPase type 2; Extracellular signal-regulated kinase 1/2; Cardiac hypertrophy; Ejection fraction
Core Tip	Myocardial infarction has been extensively validated in rats for reliably inducing post-infarction metabolic and histological changes. Combined therapy may target the extracellular signal-regulated kinase and protein kinase B/mammalian target of rapamycin signaling, both of which are central to the development of hypertrophic remodeling after myocardial infarction, along with the crosstalk between matrix metalloproteinase 9 and sarcoplasmic endoplasmic reticulum calcium ATPase type 2a, which maintains the balance between hypertrophic growth and contractile function. This could offer a new therapeutic regimen for treating early maladaptive left ventricular hypertrophy.
Citation	ShamsEldeen AM, AbdElalim MM, Mohamed NS, AbdelRahman MM, Kamar SS, AbdelKader DH, Elsharkawy SH, Rashed LA, Faisal SS, Osman WA, Selmy AM. Mesenchymal stem-derived exosomes enhance therapeutic benefits of exercise in isoproterenol-induced myocardial ischemia: Targeting ERK and Akt/mTOR signaling. World J Stem Cells 2025; In press

Received	2025-05-26 13:39
Peer-Review Started	2025-05-26 13:39
To Make the First Decision
Return for Revision	2025-06-07 05:51
Revised	2025-06-19 22:29
Second Decision	2025-09-01 00:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 10:49
Articles in Press	2025-09-08 10:49
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ISSN	1948-0210 (online)
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