Publication Name	World Journal of Gastroenterology
Manuscript ID	109947
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Targeted therapy combined with immunotherapy vs trifluridine/tipiracil with bevacizumab as late-line therapy in metastatic colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Zhao Gao, Xiao-Yan Wang, Tao Song, Zhi-Gang Shen, Xiao-Yun Wang, Shi-Kai Wu and Xuan Jin
Funding Agency and Grant Number	Funding Agency Grant Number National High Level Hospital Clinical Research Funding (Multi-Center Clinical Research Project of Peking University First Hospital) No. 2022CR65
Corresponding Author	Xuan Jin, Department of Medical Oncology, Peking University First Hospital, No. 8 Xishiku Street, Beijing 100034, China. 27051079@qq.com
Key Words	Microsatellite stable; Metastatic colorectal cancer; Immune checkpoint inhibitors; Targeted therapy; Programmed cell death 1; Trifluridine/tipiracil
Core Tip	Targeted therapy combined with anti-programmed cell death 1 immunotherapy (TP) and trifluridine/tipiracil combined with bevacizumab (TB) are two common therapies for patients with late-line therapy in microsatellite stable (MSS) metastatic colorectal cancer (mCRC). However, it is still unclear which therapy can bring better prognosis. This study aims to evaluate the effectiveness and safety of TP vs TB as the late-line regimen for MSS mCRC in the real world.
Citation	Gao Z, Wang XY, Song T, Shen ZG, Wang XY, Wu SK, Jin X. Targeted therapy combined with immunotherapy vs trifluridine/tipiracil with bevacizumab as late-line therapy in metastatic colorectal cancer. World J Gastroenterol 2025; In press

Received	2025-05-26 04:47
Peer-Review Started	2025-05-26 04:47
To Make the First Decision
Return for Revision	2025-06-04 03:08
Revised	2025-06-09 09:04
Second Decision	2025-07-11 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-11 03:09
Articles in Press	2025-07-11 03:09
Publication Fee Transferred	2025-06-10 20:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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