Publication Name	World Journal of Cardiology
Manuscript ID	109961
Country	Viet Nam

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Role of polymorphisms and microRNA levels in predicting cardiovascular events in patients with acute myocardial infarction
Manuscript Source	Invited Manuscript
All Author List	Toan Hoang Ngo and Son Kim Tran
Funding Agency and Grant Number
Corresponding Author	Son Kim Tran, Department of Internal Medicine, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Department of Internal Medicine, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, No 179, Nguyen Van Cu street, An Khanh Ward, Ninh Kieu District, Can Tho City, Can Tho 90000, Viet Nam., Can Tho 900000, Viet Nam. tkson@ctump.edu.vn
Key Words	Acute myocardial infarction; Circulating microRNA; Major adverse cardiovascular event; Coronary artery disease; MicroRNA polymorphism
Core Tip	Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide, and traditional biomarkers offer limited prognostic value. This review highlights the emerging significance of circulating microRNAs (miRNAs)-particularly miR-150, miR-208, miR-26a, and miR-483-5p and genetic polymorphisms such as rs2910164 in miR-146a in predicting AMI risk and major adverse cardiovascular events. These biomarkers regulate inflammation and endothelial dysfunction through key pathways, nuclear factor-kappaB, and nterleukin-1 receptor/toll-like receptors signaling. Integrating miRNA profiling with clinical assessment may enhance early diagnosis and enable personalized risk stratification in AMI patients.
Citation	Ngo TH, Tran SK. Role of polymorphisms and microRNA levels in predicting cardiovascular events in patients with acute myocardial infarction. World J Cardiol 2025; In press

Received	2025-05-27 04:38
Peer-Review Started	2025-05-27 04:38
To Make the First Decision
Return for Revision	2025-06-07 06:03
Revised	2025-06-14 16:36
Second Decision	2025-09-15 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-17 10:10
Articles in Press	2025-09-17 10:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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