Publication Name	World Journal of Orthopedics
Manuscript ID	110009
Country	Spain

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Nanotechnology for pain management in orthopedic surgery
Manuscript Source	Invited Manuscript
All Author List	E Carlos Rodriguez-Merchan, Javier De Andres-Ares, Alberto D Delgado-Martinez and William J Ribbans
Funding Agency and Grant Number
Corresponding Author	E Carlos Rodriguez-Merchan, MD, PhD, Department of Orthopedic Surgery, Hospital Universitario La Paz-IdiPaz, Paseo de la Castellana 261, Madrid 28046, Spain. ecrmerchan@hotmail.com
Key Words	Orthopedic surgery; Pain management; Nanotechnology; Nanotechnology-based transporter; Nanocapacitor-based device/patch
Core Tip	Nanotechnology offers encouraging alternatives for the management of pain in orthopedic surgery either as drug transporters or as capacitor device/patch. As drug transporter-based formulations for morphine, bupivacaine and lidocaine, nanotechnology permits for lengthening the duration of these drugs, and increasing the effective analgesic dose, consequently diminishing potential drug toxicity. The nanocapacitor-based technology, the NeuroCupleTM device, possibly represents an efficacious non-pharmacology method.
Citation	Rodriguez-Merchan EC, De Andres-Ares J, Delgado-Martinez AD, Ribbans WJ. Nanotechnology for pain management in orthopedic surgery. World J Orthop 2025; In press

Received	2025-05-28 09:23
Peer-Review Started	2025-05-28 09:23
To Make the First Decision
Return for Revision	2025-06-07 02:59
Revised	2025-06-10 17:32
Second Decision	2025-09-08 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 07:33
Articles in Press	2025-09-08 07:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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