Publication Name	World Journal of Diabetes
Manuscript ID	110053
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Diabetic gastrointestinal autonomic neuropathy: Integrating neuronal degeneration and gut microbial dysbiosis
Manuscript Source	Invited Manuscript
All Author List	Mei-Xia Zhou, Yu Zhao, Chen-Ling Chu, Tapas Ranjan Behera, Quan-Quan Shen and Yu-Bo Xing
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang Province LY23H050005 Zhejiang Medical Technology Project 2022RC009 Zhejiang Medical Technology Project 2023XY238 Zhejiang Medical Technology Project 2024KY645
Corresponding Author	Quan-Quan Shen, Department of Nephrology, Zhejiang Provincial People’s Hospital, No. 112 Guanghui Road, Hangzhou, Zhejiang 310014, Zhejiang, China. spring198457@sina.com
Key Words	Gut microbiota; Neuropathy; Diabetes; Enteric neuropathy; Gastrointestinal; Diabetic neuropathy
Core Tip	Diabetic gastrointestinal autonomic neuropathy (DGAN) represents a complex pathophysiological cascade driven by bidirectional interactions between hyperglycemia-induced neuronal injury and gut microbiota dysbiosis. Chronic hyperglycemia triggers oxidative stress, inflammatory pathways, and neurotrophic factor deficits, leading to damage of enteric neurons and glia. Concurrently, diabetes-associated dysbiosis reduces microbial diversity and beneficial metabolite production, which further exacerbates neuroinflammation and autonomic dysfunction. Advanced multi-omics approaches reveal these mechanisms, aiding early diagnosis through microbiome profiling and functional synaptic imaging. Therapeutic strategies targeting microbiota restoration, oxidative stress reduction, and neuroprotection show promise. Future research should prioritize large-scale clinical trials and metabolite-targeted interventions to advance personalized management of DGAN.
Citation	Zhou MX, Zhao Y, Chu CL, Behera TR, Shen QQ, Xing YB. Diabetic gastrointestinal autonomic neuropathy: Integrating neuronal degeneration and gut microbial dysbiosis. World J Diabetes 2025; In press

Received	2025-05-28 13:10
Peer-Review Started	2025-05-30 00:09
To Make the First Decision
Return for Revision	2025-06-12 02:07
Revised	2025-06-25 12:59
Second Decision	2025-08-14 03:08
Accepted by Journal Editor-in-Chief	2025-08-17 10:43
Accepted by Executive Editor-in-Chief	2025-08-19 08:21
Articles in Press	2025-08-19 08:21
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ISSN	1948-9358 (online)
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