Publication Name	World Journal of Diabetes
Manuscript ID	110108
Country	Malaysia

Category	Neurosciences
Manuscript Type	Minireviews
Article Title	Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy - mechanisms, challenges, and emerging therapeutics
Manuscript Source	Invited Manuscript
All Author List	Nayab Khalid, Nazlahshaniza Shafin, Idris Long, Hidani Hasim and Che Aishah Nazariah Ismail
Funding Agency and Grant Number
Corresponding Author	Che Aishah Nazariah Ismail, Lecturer, PhD, Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia. aishahnazariah@usm.my
Key Words	Painful diabetic neuropathy; N-methyl-D-aspartate receptor-2B; Chronic pain; Oxidative stress; Inflammation; Nociception; Glia
Core Tip	In the pathophysiology of painful diabetic neuropathy, N-methyl-D-aspartate receptor-2B plays a pivotal role. This minireview highlights how it contributes to oxidative stress, neuroinflammation, and central sensitization. It discusses the experimental and clinical data linking N-methyl-D-aspartate receptor-2B upregulation with chronic pain, evaluates emerging therapeutics targeting this receptor, and outlines translational challenges. Understanding the receptor’s molecular interplay with glial cells and signaling pathways provides valuable insight for developing multi-targeted or precision-based therapies to improve painful diabetic neuropathy management.
Citation	Khalid N, Shafin N, Long I, Hasim H, Ismail CAN. Targeting N-methyl-D-aspartate 2B receptor in painful diabetic neuropathy - mechanisms, challenges, and emerging therapeutics. World J Diabetes 2025; In press

Received	2025-05-29 06:10
Peer-Review Started	2025-06-06 09:03
First Decision by Editorial Office Director	2025-07-04 07:10
Return for Revision	2025-07-04 07:10
Revised	2025-07-31 08:25
Publication Fee Transferred
Second Decision by Editor	2025-10-21 00:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 09:42
Articles in Press	2025-12-02 09:42
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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