Publication Name	World Journal of Gastroenterology
Manuscript ID	110114
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Targeting tumor vascular endothelial cells for hepatocellular carcinoma treatment
Manuscript Source	Invited Manuscript
All Author List	Chun-Ye Zhang and Ming Yang
Funding Agency and Grant Number
Corresponding Author	Ming Yang, Assistant Professor, PhD, Department of Surgery, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, United States. minyang@uchc.edu
Key Words	Hepatocellular carcinoma; Vascular endothelial cells; Angiogenesis; Molecular signaling pathways; Therapy
Core Tip	Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, without effective treatment strategies for unresectable HCC. Tumor vascular endothelial cells have distinct features and functions from liver sinusoidal endothelial cells, lining the interior layer of cancer vascular vessels, and they contribute to tumor angiogenesis, proliferation, migration, and therapeutic resistance. Targeting liver tumor vascular endothelial cell molecular signaling pathways in the promotion of liver fibrosis, immunosuppressive cell infiltration, angiogenesis, and secretion of pro-metastatic factors is a promising strategy for HCC therapy or as a synergistic treatment.
Citation	Zhang CY, Yang M. Targeting tumor vascular endothelial cells for hepatocellular carcinoma treatment. World J Gastroenterol 2025; In press

Received	2025-05-30 05:23
Peer-Review Started	2025-05-30 05:23
To Make the First Decision
Return for Revision	2025-06-06 07:05
Revised	2025-06-21 01:04
Second Decision	2025-07-09 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-09 05:54
Articles in Press	2025-07-09 05:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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