Publication Name	World Journal of Gastroenterology
Manuscript ID	110152
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Radiofrequency ablation with or without capecitabine maintenance therapy for lung oligometastases from colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ke-Ning Li, Lei-Lei Ying, Nan Du, Ying Wang, Hao-Zhe Huang, Yao-Hui Wang, Li-Chao Xu, Qing Zhao, Ge Song, Yu-Bin Hu, Wen-Tao Li, Yan Yan, Chao Chen and Xin-Hong He
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82072034
Corresponding Author	Xin-Hong He, Department of Interventional Radiology, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, Xuhui District, Shanghai 200032, China. xinhong.he@shca.org.cn
Key Words	Colorectal cancer; Lung oligometastases; Radiofrequency ablation; Capecitabine; Maintenance therapy
Core Tip	This multicenter retrospective analysis demonstrates that adding maintenance capecitabine after achieving no evidence of disease with radiofrequency ablation (RFA) significantly improves survival outcomes in colorectal cancer patients with lung oligometastases. Compared to RFA alone, the RFA-plus-capecitabine group showed superior 5-year overall survival and significantly reduced local tumor progression, although progression-free survival was unchanged. This study provides the first evidence supporting capecitabine maintenance therapy following RFA-induced no evidence of disease as a strategy to enhance long-term survival and local control in this oligometastatic population.
Citation	Li KN, Ying LL, Du N, Wang Y, Huang HZ, Wang YH, Xu LC, Zhao Q, Song G, Hu YB, Li WT, Yan Y, Chen C, He XH. Radiofrequency ablation with or without capecitabine maintenance therapy for lung oligometastases from colorectal cancer. World J Gastroenterol 2025; In press

Received	2025-05-30 06:12
Peer-Review Started	2025-05-30 06:12
To Make the First Decision
Return for Revision	2025-06-30 07:18
Revised	2025-07-07 09:08
Second Decision	2025-08-15 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 10:59
Articles in Press	2025-08-15 10:59
Publication Fee Transferred	2025-07-09 08:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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