Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110166
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Irreversible electroporation combined with checkpoint blockade stimulates antitumor immune response in a hepatocellular carcinoma mouse model
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Li Xing, Hong-Mei Li, Xiao-Ming Pang, Ying Zhang, Ting Yang, Yan-Hong Li, De-Chuan Liu, Yang-Yang Ma and Li-Zhi Niu
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Program of Guangzhou No. 202201020024
Corresponding Author	Li-Zhi Niu, Chief Physician, PhD, Professor, Department of Oncology, Guangzhou Fuda Cancer Hospital, Jinan University, No. 2 Tangde West Road, Tianhe District, Guangzhou 510665, Guangdong Province, China. niuboshi@fudahospital.com
Key Words	Irreversible electroporation; Hepatocellular carcinoma; Programmed cell death protein 1 blockade; Cluster of differentiation 8+ T cell; Anticancer immunity
Core Tip	This study highlights the combination of irreversible electroporation and anti-programmed cell death protein 1 therapy synergistically enhances antitumor immunity by significantly increasing tumor infiltration of T cells [cluster of differentiation (CD) 4+, CD8+], natural killer cells, and B cells, elevating Th1-associated cytokine levels (interleukin-2, interferon-γ, and tumor necrosis factor-β), and upregulating CD8 messenger RNA expression. This dual approach markedly reduces tumor volume compared to monotherapies, demonstrating potentiated therapeutic efficacy and providing a novel strategy for ablation-immunotherapy integration, with potential implications for hepatocellular carcinoma.
Citation	Xing YL, Li HM, Pang XM, Zhang Y, Yang T, Li YH, Liu DC, Ma YY, Niu LZ. Irreversible electroporation combined with checkpoint blockade stimulates antitumor immune response in a hepatocellular carcinoma mouse model. World J Gastrointest Oncol 2025; In press

Received	2025-06-04 02:50
Peer-Review Started	2025-06-04 02:50
To Make the First Decision
Return for Revision	2025-06-17 04:46
Revised	2025-07-05 01:21
Second Decision	2025-08-15 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 11:03
Articles in Press	2025-08-15 11:03
Publication Fee Transferred	2025-07-10 01:35
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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