Publication Name	World Journal of Diabetes
Manuscript ID	110183
Country	China

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Observational Study
Article Title	Magnetic resonance imaging derived biomarkers for the diagnosis of type 2 diabetes with insulin resistance: A pilot study
Manuscript Source	Unsolicited Manuscript
All Author List	Bo-Wen Hou, Zheng Ran, Yi-Tong Li, Jing Zhang, Yong-Qiang Chu, Nadeer M Gharaibeh and Xiao-Ming Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81930045 National Natural Science Foundation of China 31630025
Corresponding Author	Xiao-Ming Li, PhD, Professor, Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Road, Wuhan 430030, Hubei Province, China. lilyboston2002@tjh.tjmu.edu.cn
Key Words	Type 2 diabetes mellitus; Insulin resistance; Magnetic resonance imaging; Fat infiltration; Muscle
Core Tip	This study reveals that insulin resistance (IR) in type 2 diabetes mellitus exacerbates myosteatosis via intramyocellular lipid (IMCL) accumulation and fat infiltration in paravertebral muscles, alongside vertebral fat fraction increases. Multiparametric magnetic resonance imaging sequences (quantitative Dixon and diffusion tensor imaging) identified key biomarkers (e.g., IMCL, fat-muscle ratios), and erector IMCL specifically showed high diagnostic accuracy for type 2 diabetes mellitus-IR. Multiparametric magnetic resonance imaging evaluation enables non-invasive quantification of early musculoskeletal metabolic injury, providing reliable imaging biomarkers for IR identification and stratification.
Citation	Hou BW, Ran Z, Li YT, Zhang J, Chu YQ, Gharaibeh NM, Li XM. Magnetic resonance imaging derived biomarkers for the diagnosis of type 2 diabetes with insulin resistance: A pilot study. World J Diabetes 2025; In press

Received	2025-06-03 01:34
Peer-Review Started	2025-06-05 00:09
To Make the First Decision
Return for Revision	2025-06-19 09:07
Revised	2025-07-01 08:39
Second Decision	2025-08-06 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 00:17
Articles in Press	2025-08-15 00:17
Publication Fee Transferred	2025-07-03 15:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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