Publication Name	World Journal of Hepatology
Manuscript ID	110217
Country	Bulgaria

Category	Infectious Diseases
Manuscript Type	Retrospective Study
Article Title	Some peculiarities in the abnormal course of hepatitis A in childhood
Manuscript Source	Invited Manuscript
All Author List	Valeri Velev, Toma Tomov, Metodi Popov, Latchezar Tomov, Elitsa N Golkocheva-Markova, Maria Pavlova, Tsvetelina Velikova and Yordanka Mitova-Mineva
Funding Agency and Grant Number
Corresponding Author	Valeri Velev, Associate Professor, DM, MD, PhD, Department of Infectious Diseases, Medical University of Sofia, Blvd. “Iv. Geshov” 17, Sofia 1000, Sofia-Grad, Bulgaria. velev_md@abv.bg
Key Words	Hepatitis A; Cholestatic hepatitis; Acute acalculous cholecystitis; Ascites
Core Tip	We showed that most cases of hepatitis A (HA) 30/115 (26.08%) can occur with atypical symptoms that require longer hospitalization. Most cases occur in patients with higher serum bilirubin levels, gamma-glutamyl transferase levels, and persistent icterus. High serum bilirubin levels and their prolonged retention, as well as the thickening of the gallbladder wall, can be perceived as prognostic signs of a possible transition into an atypical clinical course for the patient with HA. Atypical manifestations such as prolonged cholestasis and acute acalculous cholecystitis are not uncommon in children with HA.
Citation	Velev V, Tomov T, Popov M, Tomov L, Golkocheva-Markova EN, Pavlova M, Velikova T, Mitova-Mineva Y. Some peculiarities in the abnormal course of hepatitis A in childhood. World J Hepatol 2026; In press

Received	2025-06-03 16:00
Peer-Review Started	2025-06-03 16:00
First Decision by Editorial Office Director	2025-07-01 03:43
Return for Revision	2025-07-01 03:43
Revised	2025-07-14 20:43
Publication Fee Transferred
Second Decision by Editor	2026-01-21 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-21 08:33
Articles in Press	2026-01-21 08:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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