Publication Name	World Journal of Stem Cells
Manuscript ID	110248
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Minireviews
Article Title	Extracellular vesicles from adipose-derived stem cells in bone regeneration: Mechanisms and therapeutic advances
Manuscript Source	Invited Manuscript
All Author List	An Lin, Jia-Lu Yu, Sheng-Meng Yuan, Ying-Feng Tang, Ke-Xin Yang, Yu-Hao Wang, Fang-Jun Huo, Zhao-Rui Jin, Qi Xiao, Chao Yang and Wei-Dong Tian
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program of China 2022YFA1104400 National Natural Science Foundation of China U21A20369
Corresponding Author	Chao Yang, Department of Research and Development, Chengdu Shiliankangjian Biotechnology Co., Ltd, No. 366 Hemin Street, Chengdu High-Tech Zone, Chengdu 610213, Sichuan Province, China. yangchao1207@qq.com
Key Words	Adipose-derived stem cell; Extracellular vesicle; Bone regeneration; Fracture healing; Osteoarthritis; Osteoporosis; Therapeutic mechanism
Core Tip	Extracellular vesicles derived from adipose-derived stem cells exhibit significant potential in bone regeneration. They mediate osteogenesis, angiogenesis, and immunomodulation via bioactive molecules, with translational strategies including preconditioning, cargo engineering, and biomaterial integration. This review summarizes their efficacy in fractures, osteoarthritis, and osteoporosis, and discusses clinical translation challenges.
Citation	Lin A, Yu JL, Yuan SM, Tang YF, Yang KX, Wang YH, Huo FJ, Jin ZR, Xiao Q, Yang C, Tian WD. Extracellular vesicles from adipose-derived stem cells in bone regeneration: Mechanisms and therapeutic advances. World J Stem Cells 2025; In press

Received	2025-06-03 08:33
Peer-Review Started	2025-06-03 08:33
To Make the First Decision
Return for Revision	2025-07-03 07:21
Revised	2025-07-17 02:03
Second Decision	2025-09-05 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 10:22
Articles in Press	2025-09-08 10:22
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ISSN	1948-0210 (online)
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