Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	110353
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Timing of intervention: Assessing early vs late endoscopic and surgical interventions in acute cholangitis
Manuscript Source	Invited Manuscript
All Author List	Silpa Choday, Jad Alsheikh and Neil Vyas
Funding Agency and Grant Number
Corresponding Author	Silpa Choday, MD, Department of Internal Medicine, Creighton University School of Medicine, 3110 N Central Avenue, Phoenix, AZ 85012, United States. ushilpa19@gmail.com
Key Words	Acute cholangitis; Endoscopic retrograde cholangiopancreatography; Laparoscopic common bile duct exploration; Nationwide Readmissions Database; Readmissions; Timing
Core Tip	Timely intervention for biliary issues is crucial, as urgent and early retrograde cholangiopancreatography (ERCP) procedures generally lead to shorter hospital stays and lower costs compared to delayed interventions. Patients undergoing late ERCP face increased risks of severe complications like septic shock and respiratory failure, and higher readmission rates. While laparoscopic common bile duct exploration (LCBDE) patients experienced higher rates of certain complications (respiratory failure, bile duct perforation), adjusted analyses showed no significant difference in 30-day readmissions between LCBDE and ERCP, although LCBDE typically incurred longer stays and higher costs. Factors like older age, higher comorbidities, and Medicaid coverage were associated with increased 30-day readmission risk. Ultimately, prompt management of biliary conditions significantly influences patient outcomes, with delays often leading to a higher burden of care.
Citation	Choday S, Alsheikh J, Vyas N. Timing of intervention: Assessing early vs late endoscopic and surgical interventions in acute cholangitis. World J Gastrointest Endosc 2025; In press

Received	2025-06-05 13:48
Peer-Review Started	2025-06-05 13:48
To Make the First Decision
Return for Revision	2025-06-17 07:21
Revised	2025-06-17 23:45
Second Decision	2025-11-17 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-17 03:15
Articles in Press	2025-11-17 03:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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