Publication Name	World Journal of Stem Cells
Manuscript ID	110445
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Efficacy of extracellular vesicles derived from mesenchymal stromal cells in regulating senescence: In vitro and in vivo insights
Manuscript Source	Unsolicited Manuscript
All Author List	Shuang-Shuang Yang, Si-Yu Chen, Wen-Ya Zhuang, Jing Han, Ya Liu, Li Deng, Hui-Zhen Guo, He-Ran Ma and Yi Tan
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Technology of China 2021YFA1101502
Corresponding Author	Yi Tan, Department of Research and Development, Qilu Cell Therapy Technology Co. Ltd., No. 6 Gangyuan Road, Jinan 250100, Shandong Province, China. pkuty@126.com
Key Words	Senescence; Anti-aging; Mesenchymal stromal cells; Extracellular vesicles; Transcriptomics; Metabolomics
Core Tip	This study addresses the practical challenges of using mesenchymal stromal cell-derived extracellular vesicles (EVs) for anti-aging therapy. We developed a scalable production method and quality control standards for clinical use. Tests in cells and animals have shown that these EVs effectively decrease the expression of aging markers, repair age-related damage, reduce oxidative stress, and normalize gene activity. The key mechanisms involved in fighting oxidative stress and fine-tuning metabolism. These findings position EVs as promising, ready-to-use anti-aging treatments.
Citation	Yang SS, Chen SY, Zhuang WY, Han J, Liu Y, Deng L, Guo HZ, Ma HR, Tan Y. Efficacy of extracellular vesicles derived from mesenchymal stromal cells in regulating senescence: In vitro and in vivo insights. World J Stem Cells 2025; In press

Received	2025-06-10 04:48
Peer-Review Started	2025-06-10 04:48
To Make the First Decision
Return for Revision	2025-06-18 02:27
Revised	2025-07-01 10:07
Second Decision	2025-09-01 00:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 11:06
Articles in Press	2025-09-08 11:06
Publication Fee Transferred	2025-07-03 01:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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