Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110464
Country	China

Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	Uridine diphosphate-glucose 6-dehydrogenase-mediated glucuronidation and its emerging role in gut-liver immune regulation
Manuscript Source	Invited Manuscript
All Author List	Ye-Qiu Yang, Ning Li, Shuai Liu and Yong-Wei Yu
Funding Agency and Grant Number
Corresponding Author	Yong-Wei Yu, PhD, Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yuyongwei@zju.edu.cn
Key Words	Uridine diphosphate-glucose 6-dehydrogenase; Glucuronidation; Gut-liver axis; Hepatocellular carcinoma; Immune microenvironment
Core Tip	Uridine diphosphate-glucose 6-dehydrogenase (UGDH), a key metabolic enzyme involved in glucuronidation, is increasingly recognized for its role in hepatocellular carcinoma progression. Recent studies have revealed that dysregulated UGDH contributes not only to metabolic reprogramming but also to immune suppression by disrupting bile acid detoxification and facilitating microbial translocation from the gut. This editorial highlights the dual function of UGDH as both a metabolic and immune modulator, and introduces a novel hypothesis that positions UGDH as a potential checkpoint within the gut-liver immune axis. Understanding this interplay could lead to new therapeutic strategies targeting metabolic-immune cross-talk in gastrointestinal oncology.
Citation	Yang YQ, Li N, Liu S, Yu YW. Uridine diphosphate-glucose 6-dehydrogenase-mediated glucuronidation and its emerging role in gut-liver immune regulation. World J Gastrointest Oncol 2025; In press

Received	2025-06-10 01:46
Peer-Review Started	2025-06-10 01:46
To Make the First Decision
Return for Revision	2025-07-01 02:56
Revised	2025-07-13 14:36
Second Decision	2025-08-14 03:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-14 13:30
Articles in Press	2025-08-14 13:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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