Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	110501
Country	India

Category	Surgery
Manuscript Type	Minireviews
Article Title	Asymptomatic gallstone disease: Re-evaluating the threshold for surgical options in the era of precision medicine
Manuscript Source	Invited Manuscript
All Author List	Prakash K Sasmal, Pradeep K Singh, Ankit Sahoo and Tanmay Dutta
Funding Agency and Grant Number
Corresponding Author	Prakash K Sasmal, FACS, Full Professor, Postdoctoral Fellow, Professor, General Surgery, All India Institute of Medical Sciences, Sijua, Bhubaneshwar 751019, Odisha, India. surg_prakash@aiimsbhubaneswar.edu.in
Key Words	Cholelithiasis; Laparoscopy; Watchful waiting; Gallbladder cancer; Pancreatitis; Obstructive jaundice; Clinical decision support systems; Artificial intelligence in surgery; Bile duct injury; Health equity
Core Tip	Asymptomatic gallstones are incidentally detected on imaging. Aside from an extremely small number of patients who eventually have issues, in a few cases, life-threatening, most never become symptomatically apparent. Our treatment strategy for such patients has evolved over the years, driven by advances in imaging, laparoscopy, artificial intelligence (AI), and precision medicine. Physicians can now weigh the risk and decide who could benefit from early intervention with more advanced diagnostic and predictive tools. This review highlights how precision tools, including genomics, AI, and decision-support systems, will cause a paradigm shift in management from a one-size-fits-all approach to an individualised, patient-centred approach.
Citation	Sasmal PK, Singh PK, Sahoo A, Dutta T. Asymptomatic gallstone disease: Re-evaluating the threshold for surgical options in the era of precision medicine. World J Gastrointest Surg 2025; In press

Received	2025-06-10 07:34
Peer-Review Started	2025-06-10 07:34
To Make the First Decision
Return for Revision	2025-06-12 07:02
Revised	2025-06-23 08:08
Second Decision	2025-10-11 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-11 05:59
Articles in Press	2025-10-11 05:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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