Publication Name	World Journal of Diabetes
Manuscript ID	110502
Country	Italy

Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Urinary biomarkers of diabetic kidney disease
Manuscript Source	Invited Manuscript
All Author List	Guido Gembillo, Luca Soraci, Rossella Messina, Lorenzo Lo Cicero, Giuseppe Spadaro, Felicia Cuzzola, Michela Calderone, Maria Federica Ricca, Simona Di Piazza, Flavia Sudano, Luigi Peritore and Domenico Santoro
Funding Agency and Grant Number
Corresponding Author	Guido Gembillo, Consultant, MD, PhD, Unit of Nephrology and Dialysis, AOU “G. Martino”, University of Messina, Via Consolare Valeria n 1, Messina 98125, Sicilia, Italy. ggembillo@gmail.com
Key Words	Diabetic nephropathy; Diabetes; Renal disease; End-stage renal disease; Tubular injury; Microalbuminuria; Cystatin C; MicroRNA; Metabolomics; Proteomics
Core Tip	Diabetic kidney disease is a major complication of diabetes and a leading cause of chronic kidney disease. Traditional markers such as albuminuria and estimated glomerular filtration rate often detect damage at a late stage, limiting early intervention. Emerging urinary biomarkers including kidney injury molecule 1, neutrophil gelatinase associated lipocalin, monocyte chemoattractant protein 1, and urinary microRNAs offer earlier and more specific detection of tubular injury, inflammation, and oxidative stress. These biomarkers enhance risk assessment, disease monitoring, and evaluation of treatment response. Incorporating them into clinical practice could enable earlier diagnosis, personalized therapy, and improved outcomes in diabetic kidney disease management.
Citation	Gembillo G, Soraci L, Messina R, Lo Cicero L, Spadaro G, Cuzzola F, Calderone M, Ricca MF, Di Piazza S, Sudano F, Peritore L, Santoro D. Urinary biomarkers of diabetic kidney disease. World J Diabetes 2025; In press

Received	2025-06-09 07:30
Peer-Review Started	2025-06-10 00:07
To Make the First Decision
Return for Revision	2025-06-22 10:43
Revised	2025-07-06 10:56
Second Decision	2025-11-17 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 00:28
Articles in Press	2025-11-18 00:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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