Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110503
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Sleep disorders in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Jin Qian, Ming-Hao Ruan, Zhi-Jie Wang, Wei Dong, Jin-Yong Jia, Xiao-Chen Feng and Hui Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82270634
Corresponding Author	Hui Liu, MD, Professor, The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, No. 225 Changhai Road, Shanghai 200082, China. liuhuigg@hotmail.com
Key Words	Sleep disorders; Circadian rhythm; Clock gene; Hepatocellular carcinoma; Risk factors; Prevention strategies
Core Tip	Hepatocellular carcinoma (HCC) remains a globally prevalent malignancy, traditionally attributed to etiological factors such as viral hepatitis, alcohol-related liver disease, and metabolic dysfunction-associated fatty liver disease. Alarmingly, the global incidence of HCC continues to rise, with more than 900000 new cases reported in 2020, a trend not fully explained by these established risk factors. Emerging evidence highlights sleep disorders as a novel contributor to hepatocarcinogenesis. This review systematically explores the association between sleep disturbances and HCC pathogenesis, focusing on the underlying pathological mechanisms through which disrupted sleep patterns may drive HCC progression.
Citation	Qian J, Ruan MH, Wang ZJ, Dong W, Jia JY, Feng XC, Liu H. Sleep disorders in hepatocellular carcinoma. World J Gastrointest Oncol 2025; In press

Received	2025-06-09 08:35
Peer-Review Started	2025-06-09 08:35
To Make the First Decision
Return for Revision	2025-06-18 02:20
Revised	2025-07-02 15:20
Second Decision	2025-09-16 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-16 07:11
Articles in Press	2025-09-16 07:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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