Publication Name	World Journal of Stem Cells
Manuscript ID	110507
Country	China

Category	Cell Biology
Manuscript Type	Review
Article Title	Silent saboteurs: How microplastics disrupt stem cells and tissue regeneration
Manuscript Source	Invited Manuscript
All Author List	Jia-Hui Zheng, Yi-Ting Li, Shu-Ting Yang, Shi-Yu Jia, Li-Wei Zheng and Mian Wan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82470939, 82170921
Corresponding Author	Mian Wan, Academic Fellow, Associate Chief Physician, Associate Professor, DDS, PhD, State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu 610041, Sichuan Province, China. mianwan@scu.edu.cn
Key Words	Microplastics; Nanoplastics; Stem cell; Tissue regeneration; Mechanism; Organoids
Core Tip	Microplastics (MPs) have become significant global environmental contaminants. However, the impact of MPs on human health, particularly their effects on stem cells and tissue regeneration, remains poorly understood. This review aims to synthesize existing research on the impact of MPs on stem cell function and tissue regeneration, with a focus on the underlying mechanisms driving these effects. We also discuss the application and prospect of organoid technology derived from stem cells in the study of MP toxicity.
Citation	Zheng JH, Li YT, Yang ST, Jia SY, Zheng LW, Wan M. Silent saboteurs: How microplastics disrupt stem cells and tissue regeneration. World J Stem Cells 2025; In press

Received	2025-06-12 04:01
Peer-Review Started	2025-06-12 04:01
To Make the First Decision
Return for Revision	2025-07-03 07:22
Revised	2025-07-17 04:23
Second Decision	2025-09-15 00:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-16 10:26
Articles in Press	2025-09-16 10:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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