Publication Name	World Journal of Orthopedics
Manuscript ID	110517
Country	China

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Phosphatidylinositol-3-kinase/protein kinase B signaling dysregulation in steroid-induced osteonecrosis of the femoral head: A minireview of therapeutic implications
Manuscript Source	Invited Manuscript
All Author List	Ya-Nan Wang, Jun-Xia Jiang, Cheng-Xiang Pang, Lei Sun, Ran Sun, Feng-Ming Wang and Hong-Jiang Jiang
Funding Agency and Grant Number
Corresponding Author	Hong-Jiang Jiang, MD, President, Professor, Department of Orthopedics, Shandong Wendeng Orthopedic Hospital, No.1 Fengshan Road, Wendeng District, Weihai 264400, Shandong Province, China. wdzggys@163.com
Key Words	Femoral head necrosis; Phosphatidylinositol-3-kinase/protein kinase B signaling pathway; Glucocorticoids; Angiogenesis; Apoptosis; Molecular targeted therapy; Cell differentiation
Core Tip	Steroid-induced osteonecrosis of the femoral head (SIONFH) is a debilitating disorder associated with prolonged glucocorticoid therapy. The phosphatidylinositol-3-kinase/protein kinase B signaling pathway plays a critical role in regulating the survival, differentiation, and angiogenesis of bone cells. This mini-review highlighted how glucocorticoid-induced dysregulation of the phosphatidylinositol-3-kinase/protein kinase B pathway in osteoblasts, osteoclasts, mesenchymal stem cells, and endothelial cells contributed to the pathogenesis of SIONFH. We reviewed emerging therapeutic strategies targeting this pathway and provided new insights into potential interventions for early-stage SIONFH.
Citation	Wang YN, Jiang JX, Pang CX, Sun L, Sun R, Wang FM, Jiang HJ. Phosphatidylinositol-3-kinase/protein kinase B signaling dysregulation in steroid-induced osteonecrosis of the femoral head: A minireview of therapeutic implications. World J Orthop 2025; In press

Received	2025-06-09 10:35
Peer-Review Started	2025-06-09 10:36
To Make the First Decision
Return for Revision	2025-07-22 09:44
Revised	2025-07-28 14:05
Second Decision	2025-11-24 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-24 08:44
Articles in Press	2025-11-24 08:44
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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