Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110523
Country	China

Category	Oncology
Manuscript Type	Editorial
Article Title	Microenvironmental code of pancreatic ductal adenocarcinoma: The prognostic symphony of budding, matrix and lymphocytes
Manuscript Source	Invited Manuscript
All Author List	Qing-Qing Zhou, Yi-Meng Ren, Su-Ming Shi and Teng-Fei Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82404058 Shanghai Municipal Commission of Health and Family Planning 2024ZZ2049 Beijing Xisike Clinical Oncology Research Foundation Y-HS202401-0011
Corresponding Author	Teng-Fei Liu, PhD, Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No. 241 Huaihai West Road, Shanghai 200030, China. liutfei@alumni.sjtu.edu.cn
Key Words	Tumor budding; Fibroblast response; Tumor-infiltrating lymphocytes; Prognostic evaluation; Pancreatic ductal adenocarcinoma
Core Tip	This editorial discusses recent research article published by Alpsoy et al, focusing on the synergistic prognostic value of tumor budding, fibroblast response, and tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma. The article reviewed herein cover topics, and provide some insights for application of tumor microenvironment markers in clinical practices.
Citation	Zhou QQ, Ren YM, Shi SM, Liu TF. Microenvironmental code of pancreatic ductal adenocarcinoma: The prognostic symphony of budding, matrix and lymphocytes. World J Gastrointest Oncol 2025; In press

Received	2025-06-12 03:51
Peer-Review Started	2025-06-12 03:51
To Make the First Decision
Return for Revision	2025-07-10 05:46
Revised	2025-07-18 10:01
Second Decision	2025-08-18 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-18 06:44
Articles in Press	2025-08-18 06:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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