Publication Name	World Journal of Orthopedics
Manuscript ID	110530
Country	India

Category	Orthopedics
Manuscript Type	Observational Study
Article Title	Efficacy of intradiscal autologous platelet-rich plasma injection in chronic lumbar disc prolapse: A quasi-experimental study
Manuscript Source	Invited Manuscript
All Author List	Prabu Mounisamy, Anirudh Dwajan, Dibyajyoti Sahoo, Naveen Jeyaraman, Sathish Muthu, Swaminathan Ramasubramanian and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Lumbar disc herniation; Chronic low back pain; Platelet-rich plasma; Intradiscal injection; Functional outcome; Visual Analogue Scale; Functional Rating Index; Regenerative therapy
Core Tip	Intradiscal autologous platelet-rich plasma injection significantly reduced pain and improved function in chronic lumbar disc prolapse patients unresponsive to physiotherapy, achieving outcomes comparable to physiotherapy responders at 3 and 6 weeks. While these preliminary findings are encouraging, the brief 6-week follow-up period precludes assessment of durability, and larger studies with extended follow-up are essential to establish long-term efficacy, evaluate potential structural effects and safety.
Citation	Mounisamy P, Dwajan A, Sahoo D, Jeyaraman N, Muthu S, Ramasubramanian S, Jeyaraman M. Efficacy of intradiscal autologous platelet-rich plasma injection in chronic lumbar disc prolapse: A quasi-experimental study. World J Orthop 2025; In press

Received	2025-06-10 16:03
Peer-Review Started	2025-06-10 16:03
To Make the First Decision
Return for Revision	2025-07-04 09:06
Revised	2025-07-09 11:51
Second Decision	2025-10-20 03:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 07:55
Articles in Press	2025-10-20 07:55
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Typeset the Manuscript

ISSN	2218-5836 (online)
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