Publication Name	World Journal of Cardiology
Manuscript ID	110537
Country	Pakistan

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Systematic Reviews
Article Title	Prognostic impact of prediabetic glycated hemoglobin levels in nondiabetic patients undergoing percutaneous coronary intervention: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Sufyan Shahid, Furqan Ahmad Sethi, Shahzaib Ahmed, Akash Kumar, Muhammad Hamza Shahid, Hafsa Arshad Azam Raja, Muhammad Usama and Hafiz Muhammad Faizan Mughal
Funding Agency and Grant Number
Corresponding Author	Sufyan Shahid, Post Doctoral Researcher, MBBS, Department of Cardiology, Khawaja Muhammad Safdar Medical College, Islamia College Road, Sialkot 51300, Punjab, Pakistan. sufyanshahid09@gmail.com
Key Words	Glycated hemoglobin; Percutaneous coronary intervention; Coronary artery disease; Non-diabetic patients; Major adverse cardiovascular events
Core Tip	Patients without a formal diabetes diagnosis may still exhibit elevated glycated hemoglobin (HbA1c) levels in the prediabetic range (5.7%-6.4%), which may contribute to worse cardiovascular outcomes. This systematic review and meta-analysis examined the prognostic impact of elevated HbA1c in non-diabetic patients undergoing percutaneous coronary intervention (PCI). We found that HbA1c ≥ 5.7% is independently associated with increased long-term all-cause mortality and major adverse cardiovascular events. These findings highlight the potential value of HbA1c as a simple, cost-effective marker for post-PCI risk stratification and emphasize the need for early intervention in this high-risk group.
Citation	Shahid S, Sethi FA, Ahmed S, Kumar A, Shahid MH, Raja HAA, Usama M, Mughal HMF. Prognostic impact of prediabetic glycated hemoglobin levels in nondiabetic patients undergoing percutaneous coronary intervention: A systematic review and meta-analysis. World J Cardiol 2025; In press

Received	2025-06-10 10:39
Peer-Review Started	2025-06-10 10:40
To Make the First Decision
Return for Revision	2025-07-02 08:28
Revised	2025-07-13 20:23
Second Decision	2025-10-13 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-13 11:14
Articles in Press	2025-10-13 11:14
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ISSN	1949-8462 (online)
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