Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	110551
Country	China

Category	Gerontology
Manuscript Type	Review
Article Title	Post-endoscopic retrograde cholangiopancreatography pancreatitis: Mechanistic pathways, diagnostic benchmarks, and emerging and mitochondria-targeted therapies
Manuscript Source	Invited Manuscript
All Author List	Wei-Yi Zhao, Jin-Wei Zhao, Lu Yu and Zhong-Yang Yu
Funding Agency and Grant Number
Corresponding Author	Zhong-Yang Yu, PhD, State Key Laboratory of Cardiovascular Diseases, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China, Shanghai 200120, China. 23310158@tongji.edu.cn
Key Words	Endoscopic retrograde cholangiopancreatography; Post-endoscopic retrograde cholangiopancreatography pancreatitis; Risk stratification management; Prevention strategies
Core Tip	Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is the most common complication of ERCP. Its pathogenesis involves mechanical injury that leads to increased pressure within the pancreatic duct, thereby causing oxidative stress and an inflammatory cascade triggered by dysbiosis. Multiple risk factors are associated with the patient, procedural aspects, and the operator. Prevention strategies primarily focus on patient risk assessment and stratified management, along with optimization of pharmacological treatment and surgical approaches. Advances in treatment emphasize precise interventions and a multidisciplinary collaborative model that integrates medical resources. Future research needs to explore genetic susceptibility, novel targeted therapies, and artificial intelligence-assisted risk assessments.
Citation	Zhao WY, Zhao JW, Yu L, Yu ZY. Post-endoscopic retrograde cholangiopancreatography pancreatitis: Mechanistic pathways, diagnostic benchmarks, and emerging and mitochondria-targeted therapies. World J Gastrointest Surg 2025; In press

Received	2025-06-12 10:52
Peer-Review Started	2025-06-12 10:52
To Make the First Decision
Return for Revision	2025-06-24 14:08
Revised	2025-07-10 17:26
Second Decision	2025-10-21 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-21 07:11
Articles in Press	2025-10-21 07:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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