Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110570
Country	Canada

Category	Oncology
Manuscript Type	Editorial
Article Title	Contrast-enhanced ultrasound as a non-invasive diagnostic modality for pancreatic ductal adenocarcinoma: The question of Ki67 for study validation
Manuscript Source	Invited Manuscript
All Author List	Terence N Moyana
Funding Agency and Grant Number
Corresponding Author	Terence N Moyana, Division of Diagnostic and Molecular Pathology, The Ottawa Hospital and University of Ottawa, 501 Smyth Road, Ottawa K1H 8L6, Ontario, Canada. tmoyana@toh.ca
Key Words	Contrast-enhanced ultrasound; Quantitative parameters; Imaging modalities; Pancreatic ductal adenocarcinoma; Ki67
Core Tip	Correlations have been reported between contrast-enhanced ultrasound (CEUS) quantitative parameters and Ki67/tumor differentiation. However, the validation process is still a work in progress. Meticulous attention should be paid to subtypes of pancreatic ductal adenocarcinoma selected for testing, the suitability of Ki67 as the gold standard, the counting methodology and grade cut-offs. Overall, CEUS appears valuable in assessing pancreatic ductal adenocarcinoma. However, it should be regarded one more additional tool along with other imaging modalities such as computed tomography, magnetic resonance imaging and positron emission tomography scan. CEUS can also be augmented by endoscopic ultrasound-guided fine needle biopsy for tissue procurement. In certain situations, detective flow imaging endoscopic ultrasonography could be an alternative to CEUS.
Citation	Moyana TN. Contrast-enhanced ultrasound as a non-invasive diagnostic modality for pancreatic ductal adenocarcinoma: The question of Ki67 for study validation. World J Gastrointest Oncol 2025; In press

Received	2025-06-11 06:04
Peer-Review Started	2025-06-11 06:04
To Make the First Decision
Return for Revision	2025-07-15 06:29
Revised	2025-07-17 15:42
Second Decision	2025-08-18 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-18 06:55
Articles in Press	2025-08-18 06:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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