Publication Name	World Journal of Diabetes
Manuscript ID	110590
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Study
Article Title	Indirect bilirubin is inversely associated with diabetic retinopathy risk and is a potential predictive biomarker
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Ying Lin, Yi-Xuan Zheng, Meng-Meng Liu, Qian Liang, Meng Li, Jing Sui, Wei Qiang, Hui Guo, Bing-Yin Shi and Ming-Qian He
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Shaanxi Province 2024JC-YBQN-0828 Natural Science Foundation of Shaanxi Province 2024JC-YBMS-765 Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University XJTU1AF-CRF-2022-036 National Innovation Center for Advanced Medical Devices NMED2023AGP-013
Corresponding Author	Ming-Qian He, MD, Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, No.277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. mingqian_he@xjtufh.edu.cn
Key Words	Biomarker; Diabetic retinopathy; Indirect bilirubin; Oxidative stress; Type 2 diabetes mellitus
Core Tip	This cross-sectional study distinguished the role of indirect bilirubin (IBIL) in diabetic retinopathy (DR) risk in patients with type 2 diabetes mellitus. IBIL levels were independently associated with a lower risk of developing DR, whereas total bilirubin and direct bilirubin were not. The optimal IBIL cutoff point for the risk of developing DR was 0.735 μmol/dL, with an area under the curve (AUC) of 0.612 in the overall population. The optimal IBIL cutoff point in male patients with elevated diastolic blood pressure was 0.655 μmol/dL, with an increased AUC of 0.662. IBIL is thus a potential predictive biomarker for DR.
Citation	Lin XY, Zheng YX, Liu MM, Liang Q, Li M, Sui J, Qiang W, Guo H, Shi BY, He MQ. Indirect bilirubin is inversely associated with diabetic retinopathy risk and is a potential predictive biomarker. World J Diabetes 2025; In press

Received	2025-06-12 04:04
Peer-Review Started	2025-06-13 00:18
To Make the First Decision
Return for Revision	2025-06-27 02:15
Revised	2025-07-10 14:23
Second Decision	2025-08-08 09:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-19 08:44
Articles in Press	2025-08-19 08:44
Publication Fee Transferred	2025-07-17 14:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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