Publication Name	World Journal of Diabetes
Manuscript ID	110631
Country	China

Category	Anthropology
Manuscript Type	Clinical Trials Study
Article Title	In vitro and clinical evaluation of platelet-rich plasma combined with angioplasty in diabetic foot treatment
Manuscript Source	Unsolicited Manuscript
All Author List	Chen Huang, He-Zhu Liu, Jia-Bin Liang, Wei Zhao, Yan-Sheng Wang, Li-Fen Ruan, Wei-Zhao Zhuang, Yong-Sheng Li, Qian Wang and Yu-Kuan Tang
Funding Agency and Grant Number	Funding Agency Grant Number Medical Science and Technology Foundation of Guangdong Province A2024625 Guangzhou Municipal Science and Technology Program Key Projects 202103000002 Panyu Science and Technology Planning Project 2023-Z04-019
Corresponding Author	Yu-Kuan Tang, Director, MD, Department of Minimally Invasive Interventional Radiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, No. 8 East Fuyu Road Qiaonan Street, Panyu District, Guangzhou 511400, Guangdong Province, China. tyk20126@126.com
Key Words	Angiogenesis; Diabetic foot; Endovascular angioplasty; Platelet-rich plasma; Wound healing
Core Tip	This study investigated the effect of platelet-rich plasma (PRP) combined with endovascular angioplasty on diabetic foot ulcers (DFUs). The findings revealed that PRP improved the proliferation and migration of human umbilical vein endothelial cells, human dermal fibroblasts, and human immortalized keratinocytes. It also activated p38, Ak strain transforming and Extracellular Regulated protein Kinases1/2, and upregulated vascular endothelial growth factor receptor 2 to promote angiogenesis. PRP combined with endovascular angioplasty improved microcirculation, especially in the lower limb ischemic area, and promoted tissue repair in DFU conditions. The combination of 6% activated PRP and endovascular angioplasty demonstrated a notable effect in improving DFU conditions, providing a novel treatment option for patients with DFUs.
Citation	Huang C, Liu HZ, Liang JB, Zhao W, Wang YS, Ruan LF, Zhuang WZ, Li YS, Wang Q, Tang YK. In vitro and clinical evaluation of platelet-rich plasma combined with angioplasty in diabetic foot treatment. World J Diabetes 2025; In press

Received	2025-06-11 02:36
Peer-Review Started	2025-06-16 00:04
To Make the First Decision
Return for Revision	2025-07-04 07:14
Revised	2025-07-17 06:35
Second Decision	2025-08-26 00:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 09:38
Articles in Press	2025-09-08 09:38
Publication Fee Transferred	2025-07-20 00:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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