Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	110642
Country	Argentina

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Real-world effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome in Argentina
Manuscript Source	Invited Manuscript
All Author List	Héctor Solar Muñiz, Adriana Fernández, Verónica Busoni, María Inés Martinez, Carolina Rumbo, Silvia De Barrio, Carola Saure, Martín Balacco, Martín Gonzalo Buncuga, Corina Dlugoszweski, Alejandra Manzur, Lorena Rudi, María Dolores Matoso, Sandra Cosentino, Federico Ussher, Fernando Manzur, Julia Demarchi, Elisa Malaver, Laura Brion and Laura Ungar
Funding Agency and Grant Number	Funding Agency Grant Number Takeda Argentina SA No. TAK-633-4003
Corresponding Author	Laura Ungar, MD, Department of Medical Affairs, Takeda Argentina SA, Avenida Del Libertador 7208, Buenos Aires C1429, Argentina. laura.ungar@takeda.com
Key Words	Short bowel syndrome; Intestinal failure; Parenteral nutrition; Parenteral support; Weaning; teduglutide; Real-world
Core Tip	This multicenter real-world evidence study demonstrates the effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome-IF in the Latin American population. The results showed that teduglutide induced significant reductions in parenteral support (PS) in both adult and pediatric populations, consistent with pivotal studies, with a low incidence of mild to moderate adverse events. The findings highlight the importance of early identification of eligible patients for teduglutide (patients with reduced baseline PS volume dependence and/or favorable bowel anatomy), which may increase the likelihood of achieving PS independence. This approach could potentially reduce the morbidity associated with intestinal failure, ultimately improving long-term patient outcomes in Latin America.
Citation	Solar Muñiz H, Fernández A, Busoni V, Martínez MI, Rumbo C, De Barrio S, Saure C, Balacco M, Buncuga MG, Dlugoszweski C, Manzur A, Rui L, Matoso MD, Cosentino S, Ussher F, Manzur F, Demarchi J, Malaver E, Brion L, Ungar L. Real-world effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome in Argentina. World J Gastrointest Pharmacol Ther 2025; In press

Received	2025-06-11 09:34
Peer-Review Started	2025-06-11 09:34
To Make the First Decision
Return for Revision	2025-06-25 09:28
Revised	2025-08-14 16:16
Second Decision	2025-11-17 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-17 08:50
Articles in Press	2025-11-17 08:50
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ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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