Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	110776
Country	Egypt

Category	Pediatrics
Manuscript Type	Case Control Study
Article Title	Diagnostic and prognostic utility of D-dimer and heparin-binding protein in neonatal sepsis: A prospective case-control study
Manuscript Source	Invited Manuscript
All Author List	Hosam-Eldin M Basiouny, Soha S Allam, Alif A Allam, Shimaa Abdelsattar and Mostafa M Sira
Funding Agency and Grant Number	Funding Agency Grant Number National Liver Institute, Menoufia University, and Damietta General Hospital, Damietta, Egypt
Corresponding Author	Mostafa M Sira, MD, Professor, Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Gamal Abdel Nasser Street, Shebin El-Koom 32511, Menoufia, Egypt. msira@liver.menofia.edu.eg
Key Words	C-reactive protein; D-dimer; Heparin-binding protein; Mortality; Neonatal sepsis
Core Tip	Neonatal sepsis is a serious health problem. Although early diagnosis is critical, clinical diagnosis at presentation is difficult due to its nonspecific signs and symptoms. Although blood culture is considered the gold standard for diagnosis, unfortunately, it is not always positive. Efforts have been made to help early suspicion of sepsis, for example, using the hematological scoring system. Nonetheless, there remains a pressing need for novel laboratory markers that can help differentiate bacterial infection from other pathological conditions. The current study investigates the diagnostic and prognostic value of D-dimer and heparin-binding protein in neonatal sepsis.
Citation	Basiouny HEM, Allam SS, Allam AA, Abdelsattar S, Sira MM. Diagnostic and prognostic utility of D-dimer and heparin-binding protein in neonatal sepsis: A prospective case-control study. World J Clin Pediatr 2025; In press

Received	2025-06-16 13:07
Peer-Review Started	2025-06-16 13:07
To Make the First Decision
Return for Revision	2025-06-30 07:12
Revised	2025-07-09 03:17
Second Decision	2025-10-13 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-13 09:44
Articles in Press	2025-10-13 09:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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