Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110798
Country	India

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Evaluation of pancreatic adenocarcinoma with tumor budding and lymphocytic infiltration as prognostic marker
Manuscript Source	Invited Manuscript
All Author List	Sunil V Jagtap and Shubham S Jagtap
Funding Agency and Grant Number
Corresponding Author	Sunil V Jagtap, MD, Professor, Department of Pathology, Krishna Vishwa Vidyapeeth, Krishna Institute of Medical Sciences, Malkapur, Karad 415110, Maharashtra, India. drsvjagtap@gmail.com
Key Words	Pancreatic ductal adenocarcinoma; Tumor-infiltrating lymphocytes; Tumor Budding; Prognostic marker; Evaluation
Core Tip	Pancreatic ductal adenocarcinoma is highly invasive pancreatic neoplasm, having globally 495773 new cases and 466003 new deaths reported in 2020. This article is to evaluate the prognostic importance of tumor budding (TB) and tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinom and its correlation as prognostic marker. A high TB was a poor prognostic feature and might be a target for tumor-specific treatments. While high T-cell infiltration, especially of CD8+ T cells is linked to better outcomes. Future, TB and tumor lymphocytic infiltration should be taken into consideration and included in pathology reports. This knowledge is crucial for clinicians to better assess patient prognosis.
Citation	Jagtap SV, Jagtap SS. Evaluation of pancreatic adenocarcinoma with tumor budding and lymphocytic infiltration as prognostic marker. World J Gastrointest Oncol 2025; In press

Received	2025-06-16 01:28
Peer-Review Started	2025-06-16 01:28
To Make the First Decision
Return for Revision	2025-07-16 08:06
Revised	2025-07-18 10:23
Second Decision	2025-09-08 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-08 07:44
Articles in Press	2025-09-08 07:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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