Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110877
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Clinical significance of citrullinated glial fibrillary acidic protein in predicting outcomes in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yoon Ah Cho, Dong Woo Shin, Mo-Jong Kim, Ji-Won Park, Ji-Young Choe, Jung-Woo Lee, Sung-Hoon Moon, Akihito Ishigami, Eun Kyoung Choi and Sung-Eun Kim
Funding Agency and Grant Number	Funding Agency Grant Number Korean Society of Gastroenterology funded by the Korea Research Foundation of Internal Medicine KSG-2022-02
Corresponding Author	Sung-Eun Kim, MD, PhD, Professor, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, No. 22 Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, Anyang 14068, South Korea. sekim@hallym.or.kr
Key Words	Citrulllination; Glial fibrillary acidic protein; Hepatocellular carcinoma; Biomarker; Survival; Hepatic resection
Core Tip	High citrullinated-glial fibrillary acidic protein (cit-GFAP) expression is significantly associated with increased mortality in patients with hepatocellular carcinoma following surgical resection. Multivariate Cox regression analysis identified larger tumor size and elevated cit-GFAP expression as independent predictors of poor postoperative survival. These findings suggest the potential prognostic value of cit-GFAP levels, although further validation through independent cohort studies is necessary to confirm its clinical utility as a biomarker.
Citation	Cho YA, Shin DW, Kim MJ, Park JW, Choe JY, Lee JW, Moon SH, Ishigami A, Choi EK, Kim SE. Clinical significance of citrullinated glial fibrillary acidic protein in predicting outcomes in hepatocellular carcinoma. World J Gastrointest Oncol 2025; In press

Received	2025-06-23 11:28
Peer-Review Started	2025-06-23 11:28
To Make the First Decision
Return for Revision	2025-07-16 07:08
Revised	2025-07-29 07:28
Second Decision	2025-11-12 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-12 08:47
Articles in Press	2025-11-12 08:47
Publication Fee Transferred	2025-08-04 03:12
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Typeset the Manuscript

ISSN	1948-5204 (online)
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