Publication Name	World Journal of Experimental Medicine
Manuscript ID	110890
Country	Russia

Category	Oncology
Manuscript Type	Prospective Study
Article Title	Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant
Manuscript Source	Invited Manuscript
All Author List	Marina A Senchukova, Evgeniya Yu Zubareva, Natalia V Saidler and Lyubov V Krivolapova
Funding Agency and Grant Number	Funding Agency Grant Number Russian Science Foundation 23-25-00183
Corresponding Author	Marina A Senchukova, Scientific and Clinical Center No. 3, Petrovsky National Research Centre of Surgery, Oktyabrsky Prospekt, 3, Moscow 108840, Troitsk, Russia. masenchukova@yandex.com
Key Words	Breast cancer; Chemoresistance; Programmed death-ligand 1; Programmed cell death protein 1-ligand 1; Сytoplasmic programmed cell death protein 1 ligand 1
Core Tip	We immunohistochemically studied the expression of programmed cell death protein 1 Ligand 1 (PDCD1 LG1) in tumor cells (TCs) and immune cells (ICs) in patients with breast cancer (BC). We revealed that a lack of cytoplasmic PDCD1 LG1 (cPDCD1 LG1) expression in ≥ 20% of TCs is characteristic of more aggressive BC subtypes, namely, G3 tumors, estrogen receptor-negative status and human epidermal growth factor receptor-2 overexpression. In addition, we established that the combined assessment of the lack of cPDCD1 LG1 expression in TCs and the PDCD1 LG1 score in ICs is one of the most significant predictors associated with BC chemotherapy sensitivity.
Citation	Senchukova MA, Zubareva EY, Saidler NV, Krivolapova LV. Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant. World J Exp Med 2025; In press

Received	2025-06-18 10:24
Peer-Review Started	2025-06-18 10:24
To Make the First Decision
Return for Revision	2025-06-30 07:11
Revised	2025-07-13 20:03
Second Decision	2025-10-20 03:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 11:24
Articles in Press	2025-10-20 11:24
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ISSN	2220-315x (online)
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