Publication Name	World Journal of Clinical Cases
Manuscript ID	110897
Country	China

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Case Report
Article Title	Positron emission tomography/computed tomography in risk-factor-negative young female with malignant pleural mesothelioma: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Ai-ke-dan Ai-si-ka-er, Mo-Mo Sun and Jie Shen
Funding Agency and Grant Number	Funding Agency Grant Number the Tianjin Science and Technology Project TJWJ2025RC008
Corresponding Author	Jie Shen, Chief, MD, PhD, Professor, Department of Nuclear Medicine, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. 5020200073@nankai.edu.cn
Key Words	Pleural neoplasms; Malignant pleural mesothelioma; Positron emission tomography computed tomography; F-18 fluorodeoxyglucose; Case report
Core Tip	In China, malignant pleural mesothelioma (MPM) is characterized by low definitive diagnosis rates and high misdiagnosis frequencies due to nonspecific clinical manifestations, epidemiological rarity and under-recognition in systemic diagnosis. We present a paradigmatic case of MPM in a young female patient without documented asbestos exposure, detected by F-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT), but failed to demonstrate disseminated pleural micrometastases. This case challenges the conventional risk stratification paradigm (elderly/asbestos-exposed populations), reveals the technical limitations of F-18 FDG PET/CT in detecting localized lesions, and provides evidence-based impetus for enhancing diagnostic vigilance among clinicians and nuclear medicine specialists.
Citation	Ai-Si-Ka-Er AKD, Sun MM, Shen J. Positron emission tomography/computed tomography in risk-factor-negative young female with malignant pleural mesothelioma: A case report and review of literature. World J Clin Cases 2025; In press

Received	2025-07-03 10:02
Peer-Review Started	2025-07-04 06:04
To Make the First Decision
Return for Revision	2025-07-17 10:19
Revised	2025-07-29 09:51
Second Decision	2025-09-17 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-17 08:05
Articles in Press	2025-09-17 08:05
Publication Fee Transferred	2025-08-04 15:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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