Publication Name	World Journal of Clinical Oncology
Manuscript ID	110909
Country	United Arab Emirates

Category	Oncology
Manuscript Type	Review
Article Title	Pathogenicity of Helicobacter pylori-associated gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Shamshul Ansari and Nada Ahmed
Funding Agency and Grant Number
Corresponding Author	Shamshul Ansari, Assistant Professor, PhD, Division of Health Sciences, Higher Colleges of Technology, Baniyas, Abu Dhabi 25026, United Arab Emirates. shamshulansari483@yahoo.com
Key Words	Gastric cancer; Helicobacter pylori; Virulence factors; GagA; cagPAI; Microbiome
Core Tip	The factors beyond the well-known bacterial toxins, CagA and VacA, influence disease progression. Helicobacter pylori infection can cause DNA double-strand breaks and create a hypoxic environment in the stomach lining. This activates hypoxia-inducible factors, which promote processes like tissue remodeling, new blood vessel formation, and the appearance of cancer stem cell-like populations. At the same time, infection-driven changes in regulatory molecules such as microRNAs and long non-coding RNAs can silence tumor-suppressor genes and disrupt immune control. Together, these emerging factors amplify the damage initiated by bacterial virulence factors, accelerating the transformation of normal gastric cells into cancerous ones.
Citation	Ansari S, Ahmed N. Pathogenicity of Helicobacter pylori-associated gastric cancer. World J Clin Oncol 2025; In press

Received	2025-06-18 07:08
Peer-Review Started	2025-06-18 07:08
To Make the First Decision
Return for Revision	2025-07-19 02:02
Revised	2025-08-01 16:29
Second Decision	2025-11-12 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 04:22
Articles in Press	2025-11-13 04:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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