Publication Name	World Journal of Experimental Medicine
Manuscript ID	110917
Country	India

Category	Pathology
Manuscript Type	Basic Study
Article Title	Evaluating palmitoyl-protein thioesterase 1 in oral squamous cell carcinoma: A novel indicator of tumor behaviour and therapeutic response
Manuscript Source	Invited Manuscript
All Author List	Kurundhalingam Chinniah Pradheep Kumar, Sanjukta Sahoo, Amit Kumar Adhya, Manisha R Gaikwad, Arthi Ganapathy and Praveen Kumar Ravi
Funding Agency and Grant Number
Corresponding Author	Praveen Kumar Ravi, Assistant Professor, MD, Department of Anatomy, All India Institute of Medical Sciences, Bhubaneswar, Sijua, Patrapada, Bhubaneswar 751019, Odisha, India. praveenkumar1059@gmail.com
Key Words	Oral squamous cell carcinoma; Protein palmitoyl thioesterase-1; H-score; Prognostic biomarker; Tumor grade; TNM staging; Immunohistochemistry
Core Tip	This study explores the expression of palmitoyl-protein thioesterase 1 (PPT1) in oral squamous cell carcinoma (OSCC) using immunohistochemistry and H-score quantification. A strong positive correlation was observed between PPT1 expression and tumor grade, while a negative correlation was seen with age. These findings suggest that PPT1 may serve as a novel prognostic and therapeutic biomarker, especially in younger patients and advanced OSCC cases. The study highlights the potential of integrating molecular biomarkers like PPT1 with conventional histopathological evaluation to guide personalised treatment strategies in OSCC.
Citation	Kumar KCP, Sahoo S, Adhya AK, Gaikwad MR, Ganapathy A, Ravi PK. Evaluating palmitoyl-protein thioesterase 1 in oral squamous cell carcinoma: A novel indicator of tumor behaviour and therapeutic response. World J Exp Med 2025; In press

Received	2025-06-19 06:56
Peer-Review Started	2025-06-19 06:56
To Make the First Decision
Return for Revision	2025-07-16 08:35
Revised	2025-07-25 10:09
Second Decision	2025-11-17 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-17 08:59
Articles in Press	2025-11-17 08:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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