Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	110920
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Postoperative perforation risk after endoscopic removal of gastric gastrointestinal stromal tumors: Development and validation of a predictive nomogram
Manuscript Source	Unsolicited Manuscript
All Author List	Dong-Mei Zhang, Pan-Pan Li, Min-Hui Zhang, Zong-Xian Zhao and Ya-Bo Zhou
Funding Agency and Grant Number
Corresponding Author	Zong-Xian Zhao, MD, Department of Anorectal Surgery, Fuyang People’s Hospital, No. 501 Sanqing Road, Yingzhou District, Fuyang 236000, Anhui Province, China. 461901580@qq.com
Key Words	Gastric gastrointestinal stromal tumors; Endoscopic removal; Perforation; Nomogram; Predicting model; Logistic regression
Core Tip	Gastric gastrointestinal stromal tumors are the most common mesenchymal tumors of the gastrointestinal tract, with endoscopic resection being a preferred minimally invasive treatment. Postoperative perforation is a severe complication, necessitating a robust predictive tool. In this retrospective study, we enrolled 301 patients who underwent endoscopic removal for gastric gastrointestinal stromal tumors at Fuyang People’s Hospital. Risk factors were identified via univariate and multivariate logistic regression. A nomogram was then constructed and validated. Multivariate analysis identified tumor size and cardia/fundus location as independent risk factors. The nomogram showed good predictive performance, with an area under the receiver operating characteristic curve of 0.881 in the training cohort and 0.878 in the validation cohort, with calibration curves demonstrating consistency between predicted and observed perforation rates.
Citation	Zhang DM, Li PP, Zhang MH, Zhao ZX, Zhou YB. Postoperative perforation risk after endoscopic removal of gastric gastrointestinal stromal tumors: Development and validation of a predictive nomogram. World J Gastrointest Endosc 2025; In press

Received	2025-06-19 10:40
Peer-Review Started	2025-06-19 10:43
To Make the First Decision
Return for Revision	2025-07-11 09:23
Revised	2025-07-19 08:56
Second Decision	2025-09-16 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-16 06:21
Articles in Press	2025-09-16 06:21
Publication Fee Transferred	2025-07-21 04:04
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Typeset the Manuscript

ISSN	1948-5190 (online)
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