Publication Name	World Journal of Gastroenterology
Manuscript ID	110932
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Min Woo Lee, Jin Myung Park, In Rae Cho, Kwang Hyun Chung, Bong Seong Kim, Jin Ho Choi, Woo Hyun Paik, Ji Kon Ryu, Kyungdo Han and Sang Hyub Lee
Funding Agency and Grant Number
Corresponding Author	Sang Hyub Lee, Professor, Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, South Korea. gidoctor@snu.ac.kr
Key Words	Pancreatic cystic neoplasm; Gamma-glutamyl transferase; Biomarker; Cohort study; Epidemiology
Core Tip	Gamma-glutamyl transferase (GGT), a marker of oxidative stress and hepatic dysfunction, has been reported to be associated with metabolic diseases and malignancies including pancreatic cancer. However, its role in pancreatic cystic neoplasm (PCN) has not been investigated. In this nationwide retrospective cohort study of over 2.6 million people, higher serum GGT levels were independently associated with an increased risk of PCN. This association remained robust in subgroup and sensitivity analyses when adjusting for lag period and GGT categorization. This is the first large-scale study suggesting GGT as a potential biomarker for identifying individuals at high risk of PCN.
Citation	Lee MW, Park JM, Cho IR, Chung KH, Kim BS Choi JH, Paik WH, Ryu JK, Han K, Lee SH. Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study. World J Gastroenterol 2025; In press

Received	2025-06-19 10:47
Peer-Review Started	2025-06-19 10:49
To Make the First Decision
Return for Revision	2025-07-17 10:28
Revised	2025-07-29 08:08
Second Decision	2025-09-16 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-16 04:02
Articles in Press	2025-09-16 04:02
Publication Fee Transferred	2025-08-01 04:11
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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