Publication Name	World Journal of Gastroenterology
Manuscript ID	110942
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Epidemiology of dyspepsia and esophagogastroduodenoscopic findings in the era of Helicobacter pylori eradication
Manuscript Source	Invited Manuscript
All Author List	Suguo Suzuki, Takeshi Kanno, Tomoyuki Koike, Takashi Chiba, Kiyotaka Asanuma, Katsuaki Kato, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Waku Hatta, Kaname Uno, Akira Imatani and Atsushi Masamune
Funding Agency and Grant Number
Corresponding Author	Takeshi Kanno, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 9808575, Miyagi, Japan. kanno.takeshi@med.tohoku.ac.jp
Key Words	Dyspepsia; Helicobacter pylori; Endoscopy; Peptic ulcers; Mass screening
Core Tip	We analyzed over 23000 adults undergoing endoscopic gastric cancer screening in Japan to assess dyspepsia prevalence across Helicobacter pylori infection statuses. Dyspepsia was most prevalent (28.7%) in the post-eradication and non-infected groups, compared to 25.8% in the currently infected group. Younger age, female sex, peptic ulcers, erosive esophagitis, and post-eradication status were independently associated with dyspepsia. Despite extensive endoscopic evaluation, over 90% of cases had no organic findings. These results highlight the evolving nature of dyspepsia and its persistence in the post-Helicobacter pylori era.
Citation	Suzuki S, Kanno T, Koike T, Chiba T, Asanuma K, Kato K, Hatayama Y, Ogata Y, Saito M, Hatta W, Uno K, Imatani A, Masamune A. Epidemiology of dyspepsia and esophagogastroduodenoscopic findings in the era of Helicobacter pylori eradication. World J Gastroenterol 2025; In press

Received	2025-06-24 03:19
Peer-Review Started	2025-06-24 03:19
To Make the First Decision
Return for Revision	2025-07-14 08:46
Revised	2025-07-23 05:42
Second Decision	2025-08-25 03:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-25 07:13
Articles in Press	2025-08-25 07:13
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ISSN	1007-9327 (print) and 2219-2840 (online)
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