| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Antonio J Ruiz-Malagón, Marina Herraiz-Vilela, Raquel Serrano-Pino, Paula García-Ávila, Luis Díaz-Suárez, Ada DM Carmona-Segovia, Victor M Becerra-Munoz, Manuel Jimenez-Navarro, Isabel Arranz-Salas, Juan A López-Villodres, Alejandra Fernández-Castañer, Fernando Gutierrez-Martínez, Francisco J Rodríguez-González, Raquel Camargo-Camero, Guillermo Alcain-Martinez, Cristina Rodríguez-Díaz, Eduardo Garcia-Fuentes, María J Sánchez-Quintero and Carlos Lopez-Gomez |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministerio de Ciencia, Innovación y Universidades (Spain) |
IJCI-2017-31466 |
| Consejería de Salud y Familia de la Junta de Andalucía |
PI-0244-2021 |
| Consejería de Salud y Familia de la Junta de Andalucía |
PI-0245-2021 |
| Consejería de Salud y Familia de la Junta de Andalucía |
PI-0131-2020 |
| Consejería de Economía y Conocimiento, Empresas y Universidad, de la Junta de Andalucía |
UMA20-FEDERJA-081 |
| Consejería de Economía y Conocimiento, Empresas y Universidad, de la Junta de Andalucía |
UMA20-FEDERJA-074 |
| Consejería de Economía y Conocimiento de la Junta de Andalucía |
PAIDI-CTS-1052 |
| Consejería de Empleo, Empresa y Trabajo Autónomo de la Junta de Andalucía |
MA-INV-0031-2022-04 |
| Instituto de Salud Carlos III, Spain |
CD23/00117 |
| Instituto de Salud Carlos III, Spain |
FI23-00016 |
| Instituto de Salud Carlos III, Spain |
JR22/00067 |
| Instituto de Salud Carlos III, Spain |
CP23/00088 |
| Consejería de Salud de la Junta de Andalucía |
RC-0005-2020 |
| Consejería Salud y Familias-Junta de Andalucía |
RH-0078-2021 |
| Instituto de Salud Carlos III, Spain |
CP22/00050 |
| Universidad de Málaga |
|
|
| Corresponding Author |
Carlos Lopez-Gomez, PhD, Researcher, Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina, IBIMA Plataforma BIONAND, c/ Severo Ochoa 35, Málaga 29590, Spain. carlos.lopez@ibima.eu |
| Key Words |
Growth differentiation factor 15; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Mitochondrial stress; Intestinal permeability; Tight junctions |
| Core Tip |
Mitochondrial dysfunction in intestinal mucosa is emerging as a novel mechanism in inflammatory bowel disease pathogenesis. In the present study, we show that growth differentiation factor 15 (GDF15), a marker of mitochondrial stress, is elevated in plasma from both ulcerative colitis and Crohn’s disease patients. Furthermore, levels of GDF15 correlate with markers of inflammation and intestinal permeability. In vitro assays using colonic organoids further showed that GDF15 alters the intestinal barrier, reducing the levels of zonula occludens 1 and claudin 1, and subsequently increases intestinal permeability. Targeting GDF15 may offer a promising strategy to prevent disruption of the intestinal barrier, potentially reducing immune overactivation. |
| Citation |
Ruiz-Malagón AJ, Herraiz-Vilela M, Serrano-Pino R, García-Ávila P, Díaz-Suárez L, Carmona-Segovia AD, Becerra-Munoz VM, Jimenez-Navarro M, Arranz-Salas I, López-Villodres JA, Fernández-Castañer A, Gutierrez-Martínez F, Rodríguez-González FJ, Camargo-Camero R, Alcain-Martinez G, Rodríguez-Díaz C, García-Fuentes E, Sánchez-Quintero MJ, López-Gomez C. Growth differentiation factor 15 alters intestinal barrier and increases permeability: A new molecular target in inflammatory bowel disease. World J Gastroenterol 2025; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
