Publication Name	World Journal of Clinical Cases
Manuscript ID	110976
Country	India

Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Muscle matters: Transforming the care of intensive care unit acquired sarcopenia and myosteatosis
Manuscript Source	Invited Manuscript
All Author List	Sahil Kataria, Saketh Vinjamuri and Deven Juneja
Funding Agency and Grant Number
Corresponding Author	Deven Juneja, Director, MD, Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, 1 Press Enclave Road, New Delhi 110025, India. devenjuneja@gmail.com
Key Words	Intensive care unit acquired sarcopenia; Intensive care unit acquired weakness; Myosteatosis; Muscle atrophy; Muscle weakness
Core Tip	The growing recognition of intensive care unit (ICU)-acquired sarcopenia and myosteatosis underscores their profound impact on both short-term and long-term patient outcomes. They result from a convergence of metabolic, inflammatory, endocrine, and neuromuscular disturbances. These conditions lead to prolonged ventilation, extended ICU stays, higher mortality, and increased healthcare costs. With advancements in diagnostic technologies, such as computed tomography imaging and ultrasound, the link between ICU-related factors (e.g., mechanical ventilation, sepsis, and systemic inflammation) and muscle loss has become clearer. Early identification and management of these conditions are crucial for improving recovery rates and reducing the risk of disability. Current best practices emphasize a “bundled” approach: Optimize protein and calorie delivery, avoid deep sedation, when possible, mobilize early and often, and address deliriogenic and inflammatory factors that impede participation in rehab. These interventions, when implemented together, act synergistically to preserve muscle.
Citation	Kataria S, Vinjamuri S, Juneja D. Muscle matters: Transforming the care of intensive care unit acquired sarcopenia and myosteatosis. World J Clin Cases 2025; In press

Received	2025-06-19 11:27
Peer-Review Started	2025-06-19 11:30
To Make the First Decision
Return for Revision	2025-07-07 02:11
Revised	2025-07-19 14:51
Second Decision	2025-10-20 02:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-21 03:42
Articles in Press	2025-10-21 03:42
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ISSN	2307-8960 (online)
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