Publication Name	World Journal of Clinical Oncology
Manuscript ID	110988
Country	United States

Category	Oncology
Manuscript Type	Minireviews
Article Title	Perioperative immunotherapy in gastric cancer in the spotlight
Manuscript Source	Invited Manuscript
All Author List	Laura S Pernomian, Maria Fernanda Teixeira, Raphael LC Araujo and Pedro Luiz Serrano Uson Junior
Funding Agency and Grant Number
Corresponding Author	Raphael LC Araujo, Adjunct Professor, FACS, MD, PhD, Department of Surgery, Carolinas Medical Center, Atrium Health, 1025 Morehead Medical Drive, Charlotte, NC 28204, United States. raphael.l.c.araujo@gmail.com
Key Words	Gastric cancer; Gastroesophageal junction cancer; Perioperative treatment; Neoadjuvant treatment; Chemotherapy; Immunotherapy; Surgery; Gastrectomy
Core Tip	Immunotherapy is reshaping the treatment landscape for resectable gastric and gastroesophageal junction cancers. Despite the established benefit of perioperative leucovorin, oxaliplatin, and docetaxel chemotherapy, complete pathological response rates remain below 15%. Recent phase III trials, including KEYNOTE-585 with pembrolizumab and MATTERHORN with durvalumab, have demonstrated improved pathological responses and event-free survival, particularly in biomarker-enriched subgroups such as microsatellite instability-high or programmed death-ligand 1-positive tumors. This article summarizes the evolving evidence supporting immune checkpoint inhibitors in the perioperative setting and highlights future directions toward biomarker-driven, personalized multimodal therapy for gastric cancer.
Citation	Pernomian LS, Teixeira MF, Araujo RLC, Serrano Uson Junior PL. Perioperative immunotherapy in gastric cancer in the spotlight. World J Clin Oncol 2025; In press

Received	2025-06-23 10:16
Peer-Review Started	2025-06-24 00:37
To Make the First Decision
Return for Revision	2025-07-15 09:55
Revised	2025-07-27 21:17
Second Decision	2025-11-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 03:33
Articles in Press	2025-11-14 03:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com