Publication Name	World Journal of Nephrology
Manuscript ID	110990
Country	Spain

Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Beneficial effect of sodium-glucose cotransporter 2 inhibitors on kidney function can be just a mirage
Manuscript Source	Invited Manuscript
All Author List	María M Adeva-Andany
Funding Agency and Grant Number
Corresponding Author	María M Adeva-Andany, MD, PhD, Nephrology, Hospital Juan Cardona, Pardo Bazán, Ferrol 15406, Spain. madevaa@yahoo.com
Key Words	Sodium-glucose cotransporter-2 inhibitors; Estimated glomerular filtration rate; Glomerular hyperfiltration; osmotic diuresis; Glucosuria; Skeletal muscle mass; Serum creatinine-based estimation of glomerular filtration rate; Kidney function overestimation
Core Tip	Sodium-glucose cotransporter-2 (SGLT2) inhibitors increase long-term serum creatinine-based estimated glomerular filtration rate (GFR), but this effect may not represent a kidney protective effect. Subjects undergoing osmotic diuresis exhibit glomerular hyperfiltration. In patients receiving SGLT2 inhibitors, the elevated estimated GFR may reflect an adaptive response to osmotic diuresis rather than an improvement of kidney function. In addition, loss of skeletal muscle mass has been consistently associated with use of SGLT2 inhibitors. In patients with reduced muscle mass, serum creatinine-based estimation of GFR produces a deceptive increase of estimated GFR. In patients receiving SGLT2 inhibitors, increased estimated GFR may represent an overestimation of the factual kidney function rather than an actual improvement.
Citation	Adeva-Andany MM. Beneficial effect of sodium-glucose cotransporter 2 inhibitors on kidney function can be just a mirage. World J Nephrol 2025; In press

Received	2025-06-20 02:26
Peer-Review Started	2025-06-20 02:26
To Make the First Decision
Return for Revision	2025-07-30 08:39
Revised	2025-07-30 15:59
Second Decision	2025-09-17 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-17 07:47
Articles in Press	2025-09-17 07:47
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ISSN	2220-6124 (online)
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