Publication Name	World Journal of Orthopedics
Manuscript ID	110992
Country	Thailand

Category	Orthopedics
Manuscript Type	Review
Article Title	Intertwined roles of microRNA-155 and metformin in osteoarthritis: Novel potential diagnostic, prognostic, and therapeutic modulators
Manuscript Source	Invited Manuscript
All Author List	Mantana Paisan, Konstantinos I Papadopoulos, Alexandra Papadopoulou, Weerapong Prasongchean and Phanphen Wattanaarsakit
Funding Agency and Grant Number
Corresponding Author	Konstantinos I Papadopoulos, MD, PhD, Department of R and D, THAI StemLife, 566/3 THAI StemLife Bldg, Soi Ramkhamhaeng 39 (Thepleela 1), Prachaouthit Road, Wangthonglang, Bangkok 10330, Thailand. kostas@thaistemlife.co.th
Key Words	Osteoarthritis; MicroRNA-155; Metformin; Glucagon-like peptide 1; Renin-angiotensin aldosterone system; Cyclooxygenase 2; Adenosine monophosphate-activated protein kinase
Core Tip	In osteoarthritis (OA) and its associated risk factors, elevated microRNA-155 (miR-155) regulates systemic and local joint inflammatory mediators, extracellular matrix degradation, and chondrocyte apoptosis, with context-dependent roles in cartilage repair. MiR-155 also shows promise as a diagnostic and prognostic biomarker. Metformin exerts cartilage-protective effects via adenosine monophosphate-activated protein kinase activation, nuclear factor kappa-B inhibition, and possible modulation of miR-155 expression. Combined miR-155-targeted strategies and metformin in OA could enhance anti-inflammation, cartilage-preservation, and joint regeneration through the development of innovative treatments, including novel articular delivery systems and cell-based therapies. Further research is needed to fully understand the molecular underpinnings of this relationship.
Citation	Paisan M, Papadopoulos KI, Papadopoulou A, Prasongchean W, Wattanaarsakit P. Intertwined roles of microRNA-155 and metformin in osteoarthritis: Novel potential diagnostic, prognostic, and therapeutic modulators. World J Orthop 2025; In press

Received	2025-06-20 01:53
Peer-Review Started	2025-06-20 01:53
To Make the First Decision
Return for Revision	2025-07-10 09:06
Revised	2025-07-20 09:41
Second Decision	2025-10-20 02:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 07:17
Articles in Press	2025-10-20 07:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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