Publication Name	World Journal of Cardiology
Manuscript ID	111032
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine
Manuscript Source	Invited Manuscript
All Author List	Vaibhav Sharma
Funding Agency and Grant Number
Corresponding Author	Vaibhav Sharma, MD, Researcher, Internal Medicine, Medstar Washington Hospital Center, Washington, District of Columbia 20010, United States. vsharma3090@gmail.com
Key Words	Ryanodine receptor 2 mutations; Catecholaminergic polymorphic ventricular tachycardia; Precision medicine; Calcium signaling; Genetic cardiology; Arrhythmia management; Sudden cardiac death
Core Tip	Catecholaminergic Polymorphic Ventricular Tachycardia serves as a paradigm of precision cardiology, where a mechanistic unravelling of the ryanodine receptor 2-mediated Calcium ion channel abnormality helps in formulating a genotype-oriented treatment approach. Recent studies regarding the pathopharmacology of store overload-induced Calcium ion release, together with mitochondrial interactions, posit the possibility of a more complex pathophysiology than the classic electrical disorders. Recent milestones in the application of the CRISPR Gene editing tool, together with artificial intelligence-assisted diagnostic techniques in association with a personalized form of pharmacotherapy, have resulted in the successful treatment of 80 to 90% of the affected subjects.
Citation	Sharma V. Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine. World J Cardiol 2025; In press

Received	2025-06-23 10:44
Peer-Review Started	2025-06-23 10:44
First Decision by Editorial Office Director	2025-07-30 08:00
Return for Revision	2025-07-30 08:00
Revised	2025-08-01 06:11
Publication Fee Transferred
Second Decision by Editor	2025-12-17 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 08:19
Articles in Press	2025-12-17 08:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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